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Behind a TED-Ed Lesson: Animation + Inspiration

To celebrate George Seurat’s birthday today, we thought we’d do a deep dive behind the scenes of one of our animated lessons, How do schools of fish swim in harmony?, which is about the concept of ‘emergence’ and whose animated style just so happens to have been largely influenced by the paintings of George Seurat and his contemporaries.

Emergence refers to the spontaneous creation of sophisticated behaviors and functions from large groups of simple elements, and can be used to explain the movements of ants, fish, and birds, as well as how the tiny cells in your brain give rise to the complex thoughts, memories, and consciousness that are you.

A Sunday Afternoon on the Island of La Grande Jatte, George Seurat (1884–86)

It’s kind of like a pointillist painting. When you zoom in real close, it’s just a collection of chaotic brush strokes. But take a few steps back, and you’ll see that all of those brush strokes are working together to illustrate a complex and detailed scene.

Pointillism stems from Impressionism, and depending on the artist’s technique, the size of the brush strokes vary, but are always visible. For example, Vincent van Gogh’s The Starry Night uses larger brush strokes in the night sky. Both the above and below concept designs show the animator of this lesson testing out how different brushstrokes interact to create depth within a scene. She decided that the swirling waters would make sense as large brushstrokes, which also offered contrast to allow the small fish to stand out.

George Seurat also employed a technique called ‘divisionism’, sometimes known as ‘chromoluminarism’, in which colors were separated into individual dots or patches which interacted optically. So, rather than relying on mixing colors, painters like Seurat and Paul Signac juxtaposed contrasting colors to allow for optical mixing - which in theory would produce more vibrant and pure colors than the traditional process of mixing pigments.

Circus Sideshow (Parade de Cirque), George Seurat (1887–88)

While designing this TED-Ed lesson, George Seurat and Paul Signac’s paintings provided inspiration not just for the brushstroke technique, but also for the color palette.

This GIF of the brain and it’s neural connections draws many of its colors from Seurat’s circus series palette, while the brighter colors - such as the ones used in the title GIF above - are drawn from the more vibrant colors commonly used by Paul Signac, like in the painting below.

Notre-Dame-de-la-Garde (La Bonne-Mère), Marseilles, Paul Signac (1905-06)

Animating this lesson was an opportunity to renew a sense of wonder in our ever complex universe, whether studying it up close or from afar. We hope that watching it might do the same for you!

From the TED-Ed Lesson How do schools of fish swim in harmony? - Nathan S. Jacobs

Animation by TED-Ed // Lisa LaBracio

Cathedrals Beach, Galicia

(Image caption: New model mimics the connectivity of the brain by connecting three distinct brain regions on a chip. Credit: Disease Biophysics Group/Harvard University)

Multiregional brain on a chip

Harvard University researchers have developed a multiregional brain-on-a-chip that models the connectivity between three distinct regions of the brain. The in vitro model was used to extensively characterize the differences between neurons from different regions of the brain and to mimic the system’s connectivity.

The research was published in the Journal of Neurophysiology.

“The brain is so much more than individual neurons,” said Ben Maoz, co-first author of the paper and postdoctoral fellow in the Disease Biophysics Group in the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS). “It’s about the different types of cells and the connectivity between different regions of the brain. When modeling the brain, you need to be able to recapitulate that connectivity because there are many different diseases that attack those connections.”

“Roughly twenty-six percent of the US healthcare budget is spent on neurological and psychiatric disorders,” said Kit Parker, the Tarr Family Professor of Bioengineering and Applied Physics Building at SEAS and Core Faculty Member of the Wyss Institute for Biologically Inspired Engineering at Harvard University. “Tools to support the development of therapeutics to alleviate the suffering of these patients is not only the human thing to do, it is the best means of reducing this cost.“

Researchers from the Disease Biophysics Group at SEAS and the Wyss Institute modeled three regions of the brain most affected by schizophrenia  — the amygdala, hippocampus and prefrontal cortex.

They began by characterizing the cell composition, protein expression, metabolism, and electrical activity of neurons from each region in vitro.

“It’s no surprise that neurons in distinct regions of the brain are different but it is surprising just how different they are,” said Stephanie Dauth, co-first author of the paper and former postdoctoral fellow in the Disease Biophysics Group. “We found that the cell-type ratio, the metabolism, the protein expression and the electrical activity all differ between regions in vitro. This shows that it does make a difference which brain region’s neurons you’re working with.”

Next, the team looked at how these neurons change when they’re communicating with one another. To do that, they cultured cells from each region independently and then let the cells establish connections via guided pathways embedded in the chip.

The researchers then measured cell composition and electrical activity again and found that the cells dramatically changed when they were in contact with neurons from different regions.

“When the cells are communicating with other regions, the cellular composition of the culture changes, the electrophysiology changes, all these inherent properties of the neurons change,” said Maoz. “This shows how important it is to implement different brain regions into in vitro models, especially when studying how neurological diseases impact connected regions of the brain.”

To demonstrate the chip’s efficacy in modeling disease, the team doped different regions of the brain with the drug Phencyclidine hydrochloride — commonly known as PCP — which simulates schizophrenia. The brain-on-a-chip allowed the researchers for the first time to look at both the drug’s impact on the individual regions as well as its downstream effect on the interconnected regions in vitro.

The brain-on-a-chip could be useful for studying any number of neurological and psychiatric diseases, including drug addiction, post traumatic stress disorder, and traumatic brain injury.

"To date, the Connectome project has not recognized all of the networks in the brain,” said Parker. “In our studies, we are showing that the extracellular matrix network is an important part of distinguishing different brain regions and that, subsequently, physiological and pathophysiological processes in these brain regions are unique. This advance will not only enable the development of therapeutics, but fundamental insights as to how we think, feel, and survive.”

Katie - Champ de Mars, Paris

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When a porous solid retains its properties in liquid form

Known for their exceptional porosity that enables the trapping or transport of molecules, metal-organic frameworks (MOFs) take the form of a powder, which makes them difficult to format. For the first time, an international team led by scientists from the Institut de recherche de Chimie Paris (CNRS/Chimie ParisTech ), and notably involving Air Liquide, has evidenced the surprising ability of a type of MOF to retain its porous properties in the liquid and then glass state. Published on October 9, 2017 in Nature Materials website, these findings open the way towards new industrial applications.

Metal-organic frameworks (MOFs) constitute a particularly promising class of materials. Their exceptional porosity makes it possible to store and separate large quantities of gas, or to act as a catalyst for chemical reactions. However, their crystalline structure implies that they are produced in powder form, which is difficult to store and use for industrial applications. For the first time, a team of scientists from the CNRS, Chimie ParisTech, Cambridge University, Air Liquide and the ISIS (UK) and Argonne (US) synchrotrons has shown that the properties of a zeolitic MOF were unexpectedly conserved in the liquid phase (which does not generally favor porosity). Then, after cooling and solidification, the glass obtained adopted a disordered, non-crystalline structure that also retained the same properties in terms of porosity. These results will enable the shaping and use of these materials much more efficiently than in powder form.

Read more.

Zillertal Alps // Tom Klocker

Failing to find a single functioning stapler, the grad student struggles to keep things together.

The Boardwalk at Trouville by Claude Monet

Whistler, Canada